Guidelines for the Submission of Tissue Specimens for the Pathologic Evaluation of Influenza Virus Infections

Viral antigens and nucleic acids may be focal and sparsely distributed in patients with influenza. Larger airways (particularly primary and segmental bronchi) have the highest yield for detection of influenza viruses by IHC staining. In comparison, viral RNA is more commonly detected in lower airways. Collection of the appropriate tissues ensures the best chance of detecting the virus by immunohistochemical stains and PCR tests. Read The Full Story


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